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Methylone Legal in Canada

Methylone was first synthesized in 1996 by chemists Peyton Jacob III and Alexander Shulgin for possible use as an antidepressant. [3] Methylone has been sold for recreational purposes, with the lack of a legal ban on this compound being exploited in many countries. Anecdotal evidence from people who have tried methylone in the community suggests that there do not appear to be any negative health effects due to simply trying it at low to moderate doses and using it sparingly (but nothing can be fully guaranteed). The toxicity and long-term health effects of recreational use of methylone do not appear to have been studied in a scientific context, and the exact toxic dosage is unknown. This is because methylone has a very limited history of human use. Another suggested name is βk-MDMA or beta-keto-MDMA. Although this nomenclature did not grow because the name “methylone” was widely used before the conflicting methylone brand was noticed, the analogous names of the related chemicals βk-MDEA and βk-MBDB became the established names for these substances. In October 2011, the DEA issued an emergency ban on methylone. Previously, UK law did not specifically mention that methylone replaces MDMA in rats trained to distinguish MDMA from saline. Methylone does not replace amphetamine or hallucinogenic DOM in animals trained to distinguish between these drugs and saline.

[4] In addition, methylone, like MDMA, acts on monoaminergic systems. In vitro, methylone has one-third the effectiveness of MDMA in inhibiting platelet-serotonin buildup and about the same for its inhibitory effect on dopamine and norepinephrine transporters. [5] [6] [2] – United States, since October 21, 2011, the DEA has issued an emergency ban on methylone. It is illegal to possess and distribute The chemical name of methylone is 3,4-methylenedioxy-N-methylcathinone; Methylone is similar to MDMA in its behavioral profile. In addition, methylone, also like MDMA, acts on monoaminergic systems. In vitro, methylone has one-third the effectiveness of MDMA in inhibiting platelet-serotonin buildup and about the same for its inhibitory effect on dopamine and norepinephrine transporters. The structural formula is methylone is the substituted cathinone analogue of MDMA and the 3,4-methylenedioxy analogue of methcathinone. The only structural difference of methylone from MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine ring, forming a ketone group.

[2] “Methylone” is also a brand name for an injectable form of methylprednisolone, a corticosteroid hormone used to treat arthritis and severe allergic reactions; Therefore, methylone can be confused with it. Context aside, they can be distinguished by the fact that the name is usually capitalized when it comes to the prescription drug. In New Zealand, although methylone is not explicitly listed and does not fall under the strict definitions of an “amphetamine analogue” in the Misuse of Drugs Act, it is considered “substantially similar” to methcathinone and is therefore considered an illegal Class C drug by law enforcement agencies. Methylone was sold in New Zealand for approximately 6 months, from November 2005 to April 2006, as a substitute for MDMA under the name “Ease”. The product was withdrawn after a dispute with the government. [12] [13] Despite these behavioural and pharmacological similarities between methylone and MDMA, the observed subjective effects of the two drugs are not entirely identical. Alexander Shulgin wrote about the former:[7] Methylone and mephedrone, both used as an alternative to MDPV in bath salts, are already illegal. In the UK, methylone has been illegal since the Misuse of Drugs Act was revised on 16.04.2010. Previously, it was not specifically mentioned in UK law, as ketone β was not covered by the Misuse of Drugs Act. In March 2010, plans were announced to produce methylone and other cathinones, Class B drugs, “within weeks.” Although the revision was delayed by the dissatisfaction of the Advisory Council on the Misuse of Drugs, it was hastily adopted by the government, regardless of the Council`s opinion. The import of the compounds was immediately banned. [14] The result of these differences in pharmacology from MDMA is that methylone is less dose-effective, has more balanced catecholaminergic effects compared to serotonergic effects, and behaves more like a reuptake inhibitor such as methylphenidate than a delivery device such as amphetamine; However, methylone still has relatively robust release capabilities.

[4] The name could also come from the similarity of white crystals to legal bath products such as Epsom salts. Typically, this is methylenedioxypyrovalerone, known as MDPV. But it can also be methylone or mephedrone. It has an almost antidepressant, pleasant and positive effect, but not the unique magic of MDMA. The effects of methylone may include: The analysis of “Explosion” confirmed that the active substance is methylone. [10] [unreliable source?] Many other formulations marketed as household chemicals, as well as the pure powder, were sold. In the Netherlands, methylone is not yet included in the Opium Act, but is covered by the Medicines Act. As methylone is not officially registered, trade in methylone is prohibited. The Minister of Health has asked the New Drug Evaluation and Monitoring Group (CAM) to collect information on this substance, which could lead to a formal risk assessment. [11] To date, no research has been done on the toxicity of methylone, so nothing is known about the harmfulness of this new drug.

Although not listed in Schedule 1[17], Health Canada reports that methylone is classified as an amphetamine analogue. However, methylone has the exact chemical difference between amphetamine and cathinone – and cathinone is listed as not an amphetamine analogue, which could mean that methylone is not planned in Canada. [18] The CDSA was updated as a result of the Safe Streets Act, which moved amphetamines from Schedule 3 to Schedule 1; However, methylone was not added. [19] The two main pathways of methylone in mammals are N-demethylation to methylenedioxycathinone (MDC) and demethylation followed by Omethylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC).